Adult bi chat in barry

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Elastin is synthesized only in early life and adolescence mainly by cht vascular smooth muscles cells VSMC adu,t the cross-linking of its soluble precursor, tropoelastin. In normal aging, the elastic fibers become fragmented and the mechanical load is transferred to collagen fibers, which are times stiffer than elastic fibers. Our show that minoxidil treatment preserves elastic lamellae integrity at both ages, which is accompanied by the formation of newly synthesized elastic fibers in aged bwrry. This le to a generally decreased pulse pressure and a ificant improvement of the arterial biomechanical properties in female mice, which present an increased distensibility and a decreased rigidity of the aorta. Our studies show that minoxidil treatment reversed some of the major adverse effects of arterial aging in mice and could be an interesting anti-arterial aging agent, also potentially usable for female-targeted therapies.

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Adult bi chat in barry

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Adult bi chat in barry

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Adult bi chat in barry

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Adult bi chat in barry

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